Chimeric Antigen Receptor (CAR) T-Cell Therapy Clinical Trials at the Mario Lemieux Center for Blood Cancers

To learn more or speak to a trial coordinator, please call 1-833-UPMC-CART.

This study will enroll approximately 50 adult subjects who have relapsed or refractory (r/r) iNHL to be infused with the study treatment, axicabtagene ciloleucel, to see if their disease responds to this experimental product and if this product is safe. Axicabtagene ciloleucel is made from the subjects own white blood cells which are genetically modified and grown to fight cancer. An objective response rate of 70% is targeted.

Principal Investigator: Alison Sehgal, MD
Co-Investigators: Kathleen Dorritie, MD, Warren Shlomchik, MD
Sponsor: Kite, a Gilead Company

View eligibility criteria and the full trial at

This is a Phase 1/2, open-label, multicenter study to determine the efficacy and safety of JCAR017 in adult subjects with relapsed or refractory CLL or SLL. The study will include a Phase 1 part to determine the recommended dose of JCAR017 monotherapy in subjects with relapsed or refractory CLL or SLL, followed by a Phase 2 randomized part to assess JCAR017 monotherapy treatment versus standard of care. A separate Phase 1 cohort will assess the combination of JCAR017 and concurrent ibrutinib. In all subjects, the safety, efficacy, and pharmacokinetics (PK) of JCAR017 will be evaluated.

Principal Investigator: Kathleen Dorritie, MD
Sponsor: Juno Therapeutics, Inc.

View eligibility criteria and the full trial at