Abemaciclib

Other Names: Verzenio ®

About This Drug

Abemaciclib is used to treat cancer. It is given orally (by mouth). 

Possible Side Effects

  • Bone marrow depression. This is a decrease in the number of white blood cells, red blood cells, and platelets. This may raise your risk of infection, make you feel tired and weak (fatigue), and raise your risk of bleeding.
  • Infection
  • Headache
  • Tiredness
  • Loose bowel movements (diarrhea)
  • Nausea and throwing up (vomiting)
  • Decreased appetite (decreased hunger)
  • Pain in your abdomen 

Note: Each of the side effects above was reported in 20% or greater of patients treated with abemaciclib. Not all possible side effects are included above. 

Warnings and Precautions 

  • Severe diarrhea
  • Decrease in the number of white blood cells
  • Changes in your liver function
  • Blood clots and events such as stroke and heart attack. A blood clot in your leg may cause your leg to swell, appear red and warm, and/or cause chest pain. A blood clot in your lungs may cause trouble breathing, pain when breathing, and/or chest pain.

Note: Some of the side effects above are very rare. If you have concerns and/or questions, please discuss them with your medical team.

Important Information

  • It is important that you notify your doctor and/or nurse at the first sign of loose bowel movements (diarrhea) so they can provide you with anti-diarrhea medication and give you further instructions. Notify your doctor and/or nurse if you are taking anti-diarrhea medication and your symptoms have not improved, or are worsening after 24 hours. 

How to Take your Medication

  • Swallow the medicine whole with or without food twice daily. Take this medicine at the same time each day
  • Do not chew, break, cut or crush it.
  • If any of the tablets are broken, do not touch them with bare hands. Carefully throw away the tablets and wash your hands after handling. 
  • Missed dose: If you miss or vomit a dose, do not take the missed dose at all and do not double up on the next dose. Instead, continue with your regular dosing schedule and contact your physician. 
  • Handling: Wash your hands after handling your medicine, your caretakers should not handle your medicine with bare hands and should wear latex gloves. 
  • Storage: Store this medicine in the original container at room temperature. Discuss with your nurse or your doctor how to dispose of unused medicine.

Treating Side Effects

  • Manage tiredness by pacing your activities for the day.
  • Be sure to include periods of rest between energy-draining activities. 
  • To decrease infection, wash your hands regularly. 
  • Avoid close contact with with people who have a cold, the flu, or other infections.
  • Take your temperature as your doctor or nurse tells you, and whenever you feel like you may have a fever. 
  • To help decrease bleeding, use a soft toothbrush. Check with your nurse before using dental floss. 
  • Be very careful with knives or tools.
  • Use and electric shaver instead of a razor. 
  • Keeping your pain under control is important to your well-being. Please tell your doctor or nurse if you are experiencing pain. 
  • Drink plenty of fluids (a minimum of eight glasses per day is recommended). 
  • If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid). 
  • If you get diarrhea, eat low-fiber foods that are high in protein and calories and avoid foods that can irritate your digestive tracts or lead to cramping. 
  • Ask your nurse or doctor about medicine that can lessen or stop your diarrhea. 
  • To help with nausea and vomiting, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help lessen or stop these symptoms. 
  • To help with decreased appetite, east small, frequent meals.
  • Eat high caloric food such as pudding, ice cream, yogurt, and milkshakes. 

Food and Drug Interactions

  • Do not eat grapefruit or drink grapefruit juice while taking this medicine. Grapefruit and grapefruit juice may raise the levels of abemaciclib in your body. This could make side effects worse. 
  • Check with your doctor or pharmacist about all other prescription medicines and dietary supplements you are taking before starting this medicine as there are known drug interactions with abemaciclib. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplement to make sure that there are no interactions. 
  • Avoid the use of St. John's Wort while taking abemaciclib as this may lower the levels of the drug in your body, which can make it less effective. 

When to Call the Doctor

Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:

  • Fever of 100.5 F (38 C) or higher
  • Chills
  • Feeling dizzy or lightheaded
  • Easily bleeding or bruising
  • Your leg or arm is swollen, red, warm and/or painful
  • Wheezing and/or trouble breathing
  • Chest pain or symptoms of a heart attack. Most heart attacks involve pain in the center of the chest that lasts more than a few minutes. The pain may go away and come back. It can feel like pressure, squeezing, fullness, or pain. Sometimes pain is felt in one or both arms, the back, neck, jaw, or stomach. If any of these symptoms last 2 minutes, call 911. 
  • Loose bowel movements (diarrhea)
  • Nausea that stops you from eating or drinking and/or is not relieved by prescribed medicines
  • Throwing up more than 3 times a day
  • Lasting loss of appetite or rapid weight loss of five pounds in a week
  • Fatigue that interferes with your daily activities
  • Signs of possible liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin.
  • If you think you may be pregnant

Reproduction Warnings

  • Pregnancy warning: This drug can have harmful effects on the unborn baby. Women of child bearing potential should use effective methods of birth control during your cancer treatment and for at least 3 weeks after treatment. Let your doctor know right away if you think you may be pregnant. 
  • Breastfeeding warning: Women should not breast feed during treatment and for 3 weeks after treatment because this drug could enter the breast milk and cause harm to a breast feeding baby.
  • Fertility warning: In men, this drug may affect your ability to have children in the future. Talk with your doctor or nurse if you plan to have children. Ask for information on sperm banking. 

New September 2017