Amoxicillin (Amoxil®)

About This Drug

Amoxicillin is a penicillin antibiotic that is used to treat bacterial infections. It is sometimes used in combination to treat helicobacter pylori. It is given orally (by mouth).

Possible Side Effects

  • Nausea and vomiting (throwing up)
  • Loose bowel movements (diarrhea)
  • Rash

Note:Each of the side effects above was reported in 1% or greater of patients treated with amoxicillin. Not all possible side effects are included above.

Warnings and Precautions

  • Severe diarrhea, that can be caused by an infection called clostridium difficile
  • Allergic reactions, including anaphylaxis are rare but may happen in some patients, and may be life-threatening. Signs of allergic reaction to this drug may be swelling of the face, feeling like your tongue or throat are swelling, trouble breathing, rash, itching, fever, chills, feeling dizzy, and/or feeling that your heart is beating in a fast or not normal way. If this happens, do not take another dose of this drug. You should get urgent medical treatment.
  • If you have had a serious reaction to penicillin or other medications in the past, talk with your doctor before taking amoxicillin.

Note: Some of the side effects above are very rare. If you have concerns and/or questions, please discuss them with your medical team.

How to Take Your Medication

  • Swallow the medicine with or without food.
  • For the oral suspension only: Please refer to the instructions of the package insert or speak to your nurse and/or pharmacist for proper preparation and administration of the oral suspension.
  • Missed dose: If you vomit or miss a dose, contact your physician for instructions.
  • Storage: Store this medicine in the original container at room temperature.
  • For oral suspension only: Refrigeration is preferred for the oral suspension but not required.

Treating Side Effects

  • Drink plenty of fluids (a minimum of eight glasses per day is recommended).
  • If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid).
  • If you have diarrhea, eat low-fiber foods that are high in protein and calories and avoid foods that can irritate your digestive tracts or lead to cramping.
  • Ask your nurse or doctor about medicine that can lessen or stop your diarrhea.
  • To help with nausea and vomiting, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help or stop lessen these symptoms.
  • If you get a rash do not put anything on it unless your doctor or nurse says you may. Keep the area around the rash clean and dry. Ask your doctor for medicine if your rash bothers you.

Food and Drug Interactions

  • There are no known interactions of amoxicillin with food.
  • Check with your doctor or pharmacist about all other prescription medicines and over-the-counter medicines and dietary supplements (vitamins, minerals, herbs and others) you are taking before starting this medicine as there are known drug interactions with amoxicillin. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplements to make sure that there are no interactions.
  • There are known interactions of amoxicillin with blood thinning medicine, oral birth control pills and other medications. Ask your doctor what precautions you should take.

When to Call the Doctor

Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:

  • Nausea that stops you from eating or drinkingand/or is not relieved by prescribed medicines
  • Throwing up more than 3 times a day
  • Loose bowel movements (diarrhea) 4 times a day or loose bowel movements with lack of strength or a feeling of being dizzy
  • Blood in your stool
  • A new rash or a rash that is not relieved by prescribed medicines
  • Signs of allergic reaction: swelling of the face, feeling like your tongue or throat are swelling, trouble breathing, rash, itching, fever, chills, feeling dizzy, and/or feeling that your heart is beating in a fast or not normal way. Serious allergic reactions require immediate emergency treatment.
  • If you think you may be pregnant

Reproduction Warnings

  • Pregnancy warning: It is not known if this drug may harm an unborn child.For this reason, be sure to talk with your doctor if you are pregnant or planning to become pregnant while receiving this drug. Let your doctor know right away if you think you may be pregnant.
  • Breastfeeding warning: This drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breastfeeding during treatment with this drug because this drug can enter the breast milk and cause harm to a breastfeeding baby.
  • Fertility warning:Human fertility studies have not been done with this drug. Talk with your doctor or nurse if you plan to have children.

New April 2018

This information is intended to provide helpful health information to the general public and is not to be used in place of any medical, health, psychological, or any other kind of personal professional services. The information herein does not cover all possible uses, actions, precautions, side effects, or interactions of the medicines mentioned, nor is the information intended as medical advice for individual problems or for making an evaluation as to the risks and benefits of taking a particular medication. The dose, method of administration and contraindications for any administered medication should be confirmed before use.UPMC specifically disclaims all responsibility for any liability, loss or risk, personal or otherwise, which is incurred as a consequence, directly or indirectly, of the use and application of any medication mentioned herein.