Axitinib

Other Names: Inlyta®

About This Drug

Axitinib is a drug used to treat renal cell cancer. It is given by mouth (orally).

Possible Side Effects

  • Loose bowel movements (diarrhea)
  • Constipation (not able to move bowels)
  • High Blood Pressure
  • Tiredness
  • Decreased appetite (decreased hunger)
  • Nausea and throwing up (vomiting)
  • Difficulty speaking
  • Hand-and-foot syndrome. The palms of your hands or soles of your feet may tingle, become numb, painful, swollen, or red.
  • Weight loss
  • Weakness
  • Changes in your kidney function
  • Changes in your liver function
  • Electrolyte changes
  • Blood sugar levels may change. If you have diabetes, changes may need to be made to your diabetes medication.
  • Decrease in red blood cells. This may make you feel more tired.
  • Decrease in the number of white blood cells. This may raise your risk of infection.

Note: Each of the side effects above was reported in 20% or greater of patients treated with axitinib. Not all possible side effects are included above.

Warnings and Precautions

  • Severe high blood pressure
  • Congestive heart failure. You may be short of breath.Your arms, hands, legs and feet may swell.
  • Increased protein in your urine
  • Blood clots and events such as stroke and heart attack. A blood clot in your leg may cause your leg to swell, appear red and warm, and/or cause pain. A blood clot in your lungs may cause trouble breathing, pain when breathing, and/or chest pain.
  • Abnormal bleeding – symptoms may be coughing up blood, throwing up blood (may look like coffee grounds), red or black tarry bowel movements, abnormally heavy menstrual flow, nosebleeds or any other unusual bleeding.
  • Perforation or fistula- an abnormal hole in your stomach, intestine, esophagus, or other organ, which may be life-threatening.
  • Changes in your thyroid function
  • Changes in your central nervous system can happen. The central nervous system is made up of your brain and spinal cord. You could feel extreme tiredness, agitation, confusion, hallucinations (see or hear things that are not there), trouble understanding or speaking, loss of control of your bowels or bladder, eyesight changes, numbness or lack of strength to your arms, legs, face, or body, and coma. If you start to have any of these symptoms let your doctor know right away.
  • Changes in your liver function
  • Slow wound healing

Note: Some of the side effects above are very rare. If you have concerns and/or questions, please discuss them with your medical team.

Important Information

  • Axitinib may cause slow wound healing. It should not be given within 24 hours of surgery. If you must have emergency surgery or have an accident that results in a wound, tell the doctor that you are on axitinib.

How to Take Your Medication

  • Swallow the medicine whole with a glass of water, approximately 12 hours apart.Do not chew, break or crush it.
  • You can take the medicine with or without food.
  • Missed dose: If you vomit or miss a dose, take your next dose at the regular time.  Do not take 2 doses at the same time
  • Handling: Wash your hands after handling your medicine, your caretakers should not handle your medicine with bare hands and should wear latex gloves.
  • This drug may be present in the saliva, tears, sweat, urine, stool, vomit, semen, and vaginal secretions. Talk to your doctor and/or your nurse about the necessary precautions to take during this time.
  • Storage: Store this medicine in the original container at room temperature. Discuss with your nurse or your doctor how to dispose of unused medicine.

Treating Side Effects

  • Manage tiredness by pacing your activities for the day.
  • Be sure to include periods of rest between energy-draining activities.
  • To decrease infection, wash your hands regularly.
  • Avoid close contact with people who have a cold, the flu, or other infections.
  • Take your temperature as your doctor or nurse tells you, and whenever you feel like you may have a fever.
  • Drink plenty of fluids (a minimum of eight glasses per day is recommended).
  • If you get diarrhea, eat low-fiber foods that are high in protein and calories and avoid foods that can irritate your digestive tracts or lead to cramping.
  • Ask your nurse or doctor about medicine that can lessen or stop your diarrhea.
  • Ask your doctor or nurse about medicines that are available to help stop or lessen constipation.
  • If you are not able to move your bowels, check with your doctor or nurse before you use enemas, laxatives, or suppositories.
  • If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid).
  • To help with nausea and vomiting, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help or stop lessen these symptoms
  • To help with decreased appetite, eat small, frequent meals
  • Eat high caloric food such as pudding, ice cream, yogurt and milkshakes.
  • To help with weight loss, drink fluids that contribute calories (whole milk, juice, soft drinks, sweetened beverages, milkshakes, and nutritional supplements) instead of water.
  • Include a source of protein at every meal and snack, such as meat, poultry, fish, dry beans, tofu, eggs, nuts, milk, yogurt, cheese, ice cream, pudding, and nutritional supplements.
  • Avoid sun exposure and apply sunscreen routinely when outdoors.
  • If you have diabetes, keep good control of your blood sugar level. Tell your nurse or your doctor if your glucose levels are higher or lower than normal.
  • If you get a rash do not put anything on it unless your doctor or nurse says you may. Keep the area around the rash clean and dry. Ask your doctor for medicine if your rash bothers you.

Food and Drug Interactions

  • Do not eat grapefruit or drink grapefruit juice while taking this medicine.Grapefruit and grapefruit juice may raise the levels of axitinib in your body. This could make side effects worse.
  • Check with your doctor or pharmacist about all other prescription medicines and dietary supplements you are taking before starting this medicine as there are known drug interactions with axitinib. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplement to make sure that there are no interactions.
  • Avoid the use of St. John’s Wort while taking axitinib as this may lower the levels of the drug in your body, which can make it less effective

When to Call the Doctor

Call your doctor or nurse if you have and of these symptoms and/or any new or unusual symptoms:

  • Fever of 100.5 F (38 C) or higher
  • Chills
  • A headache that does not go away
  • Blurry vision or other changes in eyesight
  • Confusion and/or agitation
  • Hallucinations
  • Trouble understanding or speaking
  • Seizures
  • Numbness or lack of strength to your arms, legs, face, or body
  • Wheezing and/or trouble breathing
  • Swelling of legs, ankles, or feet
  • Weight gain of 5 pounds in one week (fluid retention) or unexplained weight gain
  • Severe Abdominal pain that does not go away
  • Nausea that stops you from eating or drinkingor relieved by prescribed medicine
  • Throwing up more than 3 times a day
  • Pain in your abdomen that does not go away
  • Difficulty swallowing
  • Loose bowel movements (diarrhea) 4 times a day or loose bowel movements with lack of strength or a feeling of being dizzy
  • No bowel movement in 3 days or when you feel uncomfortable.
  • Lasting loss of appetite or rapid weight loss of five pounds in a week
  • Fatigue that interferes with your daily activities
  • Abnormal blood sugar
  • Unusual thirst, passing urine often, headache, sweating, shakiness, irritability, rapid and deep breathing
  • Decreased urine, or very dark urine
  • Blood in your urine, vomit (bright red or coffee-ground) and/or stools ( bright red, or black/tarry)
  • Coughing up blood
  • Painful, red, or swollen areas on your hands or feet.
  • Numbness and/or tingling of your hands and/or feet
  • Signs of possible liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin
  • Your leg or arm is swollen, red, warm and/or painful
  • Chest pain or symptoms of a heart attack. Most heart attacks involve pain in the center of the chest that lasts more than a few minutes. The pain may go away and come back. It can feel like pressure, squeezing, fullness, or pain. Sometimes pain is felt in one or both arms, the back, neck, jaw, or stomach. If any of these symptoms last 2 minutes, call 911.
  • Symptoms of a stroke such as sudden numbness or weakness of your face, arm, or leg, mostly on one side of your body; sudden confusion, trouble speaking or understanding; sudden trouble seeing in one or both eyes; sudden trouble walking, feeling dizzy, loss of balance or coordination; or sudden, bad headache with no known cause.If you have any of these symptoms for 2 minutes, call 911.
  • If you think you may be pregnant or may have impregnated your partner

Reproduction Warnings

  • Pregnancy warning: This drug may have harmful effects on the unborn baby. Women of child bearing potential should use effective methods of birth control during your cancer treatment. Men with female partners of child bearing potential should use effective methods of birth control during your cancer treatment. Let your doctor know right away if you think you may be pregnant or may have impregnated your partner.
  • Breastfeeding warning: It is not known if this drug passes into breast milk.  For this reason, women should talk to their doctor about the risks and benefits of breast feeding during treatment with this drug because this drug may enter the breast milk and cause harm to a breast feeding baby.
  • Fertility warning: Human fertility studies have not been done with this drug. Talk with your doctor or nurse if you plan to have children.Ask for information on sperm or egg banking.

Revised January 2018

This information is intended to provide helpful health information to the general public and is not to be used in place of any medical, health, psychological, or any other kind of personal professional services.  The information herein does not cover all possible uses, actions, precautions, side effects, or interactions of the medicines mentioned, nor is the information intended as medical advice for individual problems or for making an evaluation as to the risks and benefits of taking a particular medication.  The dose, method of administration and contraindications for any administered medication should be confirmed before use.  UPMC specifically disclaims all responsibility for any liability, loss or risk, personal or otherwise, which is incurred as a consequence, directly or indirectly, of the use and application of any medication mentioned herein.