Brigatinib (AlunbrigĀ®)

Brigatinib

About This Drug

Brigatinib is used to treat cancer. It is given orally (by mouth).

Possible Side Effects

  • Nausea
  • Loose bowel movements (diarrhea)
  • Tiredness
  • Cough
  • Headache

Note: Each of the side effects above was reported in 25% or greater of patients treated with brigatinib. Not all possible side effects are included above.

Warnings and Precautions

  • Inflammation (swelling) of the lungs. You may have a dry cough or trouble breathing.
  • High blood pressure. Your doctor will check your blood pressure as needed.
  • Decrease in heart rate may occur. Your doctor will monitor your heart rate as needed.
  • Blurred vision or other changes in eyesight
  • Muscle tissue injury, you may have unexplained muscle pain, tenderness or weakness
  • May affect pancreas function. Your doctor will check your pancreas function as needed.
  • Blood sugar levels may change. If you have diabetes, changes may need to be made to your diabetes medication.

How to Take Your Medication

  • Swallow the medicine whole with or without food. Do not chew, break or crush it.
  • Missed dose: If you vomit or miss a dose, take your next dose at the regular time. Do not take 2 doses at the same time.
  • Handling: Wash your hands after handling your medicine, your caretakers should not handle your medicine with bare hands and should wear latex gloves.
  • This drug may be present in the saliva, tears, sweat, urine, stool, vomit, semen, and vaginal secretions. Talk to your doctor and/or your nurse about the necessary precautions to take during this time.
  • Storage: Store this medicine in the original container at room temperature. Discuss with your nurse or your doctor how to dispose of unused medicine.

Treating Side Effects

  • Drink plenty of fluids (a minimum of eight glasses per day is recommended).
  • If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid).
  • To help with nausea and vomiting, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help or stop lessen these symptoms.
  • Manage tiredness by pacing your activities for the day. Be sure to include periods of rest between energy-draining activities.
  • Keeping your pain under control is important to your well-being. Please tell your doctor or nurse if you are experiencing pain.
  • If you have diabetes, monitor your blood sugar level. Tell your nurse or your doctor if your glucose levels are higher or lower than normal.

Food and Drug Interactions

  • Check with your doctor or pharmacist about all other prescription medicines and dietary supplements you are taking before starting this medicine as there are known drug interactions with brigatinib. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplement to make sure that there are no interactions.
  • Do not eat grapefruit or drink grapefruit juice while taking this medicine. Grapefruit and grapefruit juice may raise the levels of brigatinib in your body. This could make side effects worse.

When to Call the Doctor

Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:

  • Fever of 100.5 F (38 C) or higher
  • Chills
  • Feeling dizzy or lightheaded
  • Pain in your chest
  • Dry cough
  • Wheezing or trouble breathing
  • A headache that does not go away
  • Blurry vision or other changes in eyesight
  • Nausea that stops you from eating or drinking, and/or is not relieved by prescribed medicines
  • Loose bowel movements (diarrhea) 4 times a day or loose bowel movements with lack of strength or a feeling of being dizzy
  • Fatigue that interferes with your daily activities
  • Abnormal blood sugar
  • Unusual thirst, passing urine often, headache, sweating, shakiness, irritability
  • Unexplained muscle pain, tenderness or weakness
  • If you think you may be pregnant or if you have impregnated your partner

Reproduction Warnings

  • Pregnancy warning: This drug can have harmful effects on the unborn baby. Women of child bearing potential should use effective methods of birth control during your cancer treatment and for at least 4 months after treatment. Men with female partners of child bearing potential should use effective methods of birth control during your cancer treatment and for at least 3 months after your cancer treatment. Let your doctor know right away if you think you may be pregnant or may have impregnated your partner. Birth control pills (oral contraceptives) may not be effective with this medication.
  • Breast feeding warning: Women should not breast feed during treatment and for 1 week after treatment because this drug could enter the breast milk and cause harm to a breast feeding baby.
  • Infertility warning: In men, this drug may affect your ability to have children in the future. Talk with your doctor or nurse if you plan to have children. Ask for information on sperm banking.

Revised June 2017