Glasdegib (Daurismo™)

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About This Drug

Glasdegib is used to treat cancer. It is given orally (by mouth).

Possible Side Effects

  • Bone marrow suppression. This is a decrease in the number of white blood cells, red blood cells, and platelets. This may raise your risk of infection, make you tired and weak (fatigue), and raise your risk of bleeding.
  • Fever in the setting of decreased white blood cells, which is a serious condition that can be life-threatening
  • Soreness of the mouth and throat. You may have red areas, white patches, or sores in your mouth that hurt.
  • Nausea
  • Constipation (unable to move bowels)
  • Abnormal bleeding – symptoms may be coughing up blood, throwing up blood (may look like coffee grounds), red or black tarry bowel movements, abnormally heavy menstrual flow, nosebleeds or any other unusual bleeding.
  • Swelling of your legs, ankles and/or feet
  • Tiredness
  • Decreased appetite (decreased hunger)
  • Muscle and bone pain
  • Changes in the way food and drinks taste
  • Trouble breathing
  • Rash

Note: Each of the side effects above was reported in 20% or greater of patients treated with glasdegib. Not all possible side effects are included above.

Warnings and Precautions

  • Increased risk of abnormal heartbeats/EKG

Important Information

  • Do not donate blood during your treatment and for at least 30 days after your treatment.
  • Males should not donate sperm during your treatment and for at least 30 days after your treatment because this drug may be present in semen and may cause harm to a baby. 

How to Take Your Medication

  • Swallow the medicine whole with or without food. Do not crush or split tablets.
  • Take this medicine at approximately the same time each day.
  • Missed dose: If you miss a dose, and it is less than 12 hours until your next dose, then skip the missed dose and go back to your normal schedule. If you miss a dose, and it is more than 12 hours until your next dose, take the missed dose. Do not take 2 doses within 12 hours. Do not take 2 doses at the same time or extra doses. Do not replace a vomited dose. If you vomit a dose or miss a dose, contact your doctor.
  • Handling: Wash your hands after handling your medicine, your caretakers should not handle your medicine with bare hands and should wear latex gloves.
  • This drug may be present in the saliva, tears, sweat, urine, stool, vomit, semen, and vaginal secretions. Talk to your doctor and/or your nurse about the necessary precautions to take during this time.
  • Storage: Store this medicine in the original container at room temperature.
  • Disposal of unused medicine: Do not flush any expired and/or unused medicine down the toilet or drain unless you are specifically instructed to do so on the medication label. Some facilities have take-back programs and/or other options. If you do not have a take-back program in your area, then please discuss with your nurse or your doctor how to dispose of unused medicine.

Treating Side Effects

  • Manage tiredness by pacing your activities for the day.
  • Be sure to include periods of rest between energy-draining activities.
  • To decrease the risk of infection, wash your hands regularly.
  • Avoid close contact with people who have a cold, the flu, or other infections.
  • Take your temperature as your doctor or nurse tells you, and whenever you feel like you may have a fever.
  • To help decrease bleeding, use a soft toothbrush. Check with your nurse before using dental floss.
  • Be very careful when using knives or tools.
  • Use an electric shaver instead of a razor.
  • To help with nausea and vomiting, eat small, frequent meals instead of three large meals a day.
  • Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help or stop lessen these symptoms.
  • Drink plenty of fluids (a minimum of eight glasses per day is recommended).
  • Mouth care is very important. Your mouth care should consist of routine, gentle cleaning of your teeth or dentures and rinsing your mouth with a mixture of 1/2 teaspoon of salt in 8 ounces of water or 1/2 teaspoon of baking soda in 8 ounces of water. This should be done at least after each meal and at bedtime.
  • If you have mouth sores, avoid mouthwash that has alcohol. Also avoid alcohol and smoking because they can bother your mouth and throat.
  • Ask your doctor or nurse about medicines that are available to help stop or lessen constipation.
  • If you are not able to move your bowels, check with your doctor or nurse before you use enemas, laxatives, or suppositories.
  • If you get a rash do not put anything on it unless your doctor or nurse says you may. Keep the area around the rash clean and dry. Ask your doctor for medicine if your rash bothers you.
  • To help with decreased appetite, eat small, frequent meals. Eat foods high in calories and protein, such as meat, poultry, fish, dry beans, tofu, eggs, nuts, milk, yogurt, cheese, ice cream, pudding, and nutritional supplements.
  • Consider using sauces and spices to increase taste. Daily exercise, with your doctor’s approval, may increase your appetite.
  • Taking good care of your mouth may help food taste better and improve your appetite 
  • Keeping your pain under control is important to your well-being. Please tell your doctor or nurse if you are experiencing pain.

Food and Drug Interactions

  • This drug may interact with grapefruit and grapefruit juice. Talk to your doctor as this could make side effects worse.
  • Check with your doctor or pharmacist about all other prescription medicines and over-the-counter medicines and dietary supplements (vitamins, minerals, herbs and others) you are taking before starting this medicine as there are known drug interactions with glasdegib. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplements to make sure that there are no interactions.
  • Avoid the use of St. John’s Wort while taking glasdegib as this may lower the levels of the drug in your body, which can make it less effective.

When to Call the Doctor

Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:

  • Fever of 100.5 F (38 C) or higher
  • Chills
  • Tiredness that interferes with your daily activities
  • Feeling dizzy or lightheaded
  • Easy bleeding or bruising
  • Feeling that your heart is beating fast or in a not normal way (palpitations)
  • Wheezing or trouble breathing
  • Nausea that stops you from eating or drinking and/or is not relieved by prescribed medicines
  • Pain in your mouth or throat that makes it hard to eat or drink
  • Lasting loss of appetite or rapid weight loss of five pounds in a week
  • No bowel movement in 3 days or when you feel uncomfortable
  • Blood in your urine, vomit (bright red or coffee-ground) and/or stools (bright red, or black/tarry)
  • Coughing up blood
  • Weight gain of 5 pounds in one week (fluid retention)
  • Swelling of your legs, ankles and/or feet
  • New rash and/or itching
  • Rash that is not relieved by prescribed medicines
  • Pain that does not go away, or is not relieved by prescribed medicines
  • If you think you may be pregnant or may have impregnated your partner

Reproduction Warnings

  • Pregnancy warning: This drug can have harmful effects on the unborn baby. Women of child bearing potential should use effective methods of birth control during your cancer treatment and
  • for at least 30 days after treatment. Men with female partners of child bearing potential should use a condom during your cancer treatment and for at least 30 days after your cancer treatment. Men should use condoms even after a successful vasectomy. Let your doctor know right away if you think you may be pregnant or may have impregnated your partner.
  • Breastfeeding warning: Women should not breast feed during treatment and for at least 30 days after treatment because this drug could enter the breast milk and cause harm to a breastfeeding baby.
  • Fertility warning: In men, this drug may affect your ability to have children in the future. Talk with your doctor or nurse if you plan to have children. Ask for information on sperm banking.

New December 2018