Moxetumomab pasudotox-tdfk

Other Names: (Lumoxiti™)

About This Drug

Moxetumomab pasudotox-tdfk is used to treat cancer. It is given in the vein (IV).

Possible Side Effects

  • Bone marrow suppression. This is a decrease in the number of white blood cells, red blood cells, and platelets. This may raise your risk of infection, make you feel more tired, and may raise your risk of bleeding.
  • Nausea 
  • Constipation (unable to move bowels)
  • Diarrhea (loose bowel movements)
  • Tiredness
  • Swelling of your legs, ankles and/or feet
  • Fever
  • Changes in your liver function
  • Headache
  • Electrolyte changes
  • Changes in your kidney function\
  • While you are getting this drug in your vein (IV), you may have a reaction to the drug. Sometimes you may be given medication to stop or lessen these side effects. Your nurse will check you closely for these signs: fever or shaking chills, flushing, facial swelling, feeling dizzy, headache, trouble breathing, rash, itching, chest tightness, or chest pain. These reactions may happen after your infusion. If this happens, call 911 for emergency care.

Note: Each of the side effects above was reported in 20% or greater of patients treated with Moxetumomab pasudotox-tdfk. Not all possible side effects are included above.

Warnings and Precautions

  • A syndrome called capillary leak syndrome where fluid and protein can leak from your blood vessels into your tissues, which can be life-threatening. This can cause a decrease in your blood protein level and blood pressure and fluid can accumulate in your tissues and/or lungs.
  • A syndrome called hemolytic uremic syndrome that affects your red blood cells, platelets, and blood vessels in your kidneys, which can cause kidney failure, and can be life-threatening.
  • Severe infusion-related reactions
  • Severe electrolyte changes
  • Severe changes in your kidney function, which can cause kidney failure

Note: Some of the side effects above are very rare. If you have concerns and/or questions, please discuss them with your medical team. 

Treating Side Effects

  • Manage tiredness by pacing your activities for the day. 
  • Be sure to include periods of rest between energy-draining activities.
  • To decrease the risk of infection, wash your hands regularly.
  • Avoid close contact with people who have a cold, the flu, or other infections. 
  • Take your temperature as your doctor or nurse tells you, and whenever you feel like you may have a fever. 
  • To help decrease bleeding, use a soft toothbrush. Check with your nurse before using dental floss. 
  • Be very careful when using knives or tools.
  • Use an electric shaver instead of a razor.
  • Drink plenty of fluids (a minimum of eight glasses per day is recommended). Your doctor may want you to drink additional amount of fluids of up to twelve 8-oz glasses of fluids every 24 hours on days 1 through day 8 of each treatment cycle you receive. 
  • If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack of water in the body from losing too much fluid).
  • To help with nausea and vomiting, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help or stop lessen these symptoms. 
  • If you have diarrhea, eat low-fiber foods that are high in protein and calories and avoid foods that can irritate your digestive tracts or lead to cramping. 
  • Ask your nurse or doctor about medicine that can lessen or stop your diarrhea and/or constipation. 
  • If you are not able to move your bowels, check with your doctor or nurse before you use enemas, laxatives, or suppositories.
  • Infusion reactions may occur after your infusion. If this happens, call 911 for emergency care.

Food and Drug Interactions

  • There are no known interactions of Moxetumomab pasudotox-tdfk with food.
  • This drug may interact with other medicines. Tell your doctor and pharmacist about all the prescription and over-the-counter medicines and dietary supplements (vitamins, minerals, herbs and others) that you are taking at this time. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplements to make sure that there are no interactions.
  • The safety and use of dietary supplements and alternative diets are often not known. Using these might affect your cancer or interfere with your treatment. Do not use dietary supplements or alternative diets without your cancer doctor's help. 

When to Call the Doctor

Call your doctor or nurse if you have any of the following symptoms and/or any new or unusual symptoms:

  • Fever of 100.5 F (38 C) or above
  • Chills
  • Fatigue that interferes with your daily activities 
  • Feeling dizzy or lightheaded 
  • Easy bleeding or bruising 
  • Confusion 
  • Changes in mood 
  • Symptoms of a seizure such as confusion, blacking out, passing out, loss of hearing or vision, blurred vision, unusual smells or tastes (such as burning rubber), trouble talking, tremors or shaking in parts or all of the body, repeated body movements, tense muscles that do not relax, and loss of control of urine and bowels. If you or your family member suspects you are having a seizure, call 911 right away.
  • Wheezing and/or trouble breathing 
  • Nausea that stops you from eating or drinking and/or is not relieved by prescribed medicines 
  • Throwing up more than 3 times a day
  • No bowel movement in 3 days or when you feel uncomfortable 
  • Diarrhea, 4 times in one day or diarrhea with lack of strength or a feeling of being dizzy 
  • Blood in your stools (bright red, or black/tarry) 
  • Pain in your abdomen 
  • Weight gain of 5 pounds in one week (fluid retention) 
  • Swelling of your face, legs, ankles and/or feet 
  • Decreased urine, or very dark urine
  • Blood in urine 
  • Numbness or tingling around your mouth, or hands or feet 
  • Unexplained muscle stiffness 
  • Twitching, spasms or cramps 
  • Signs of possible liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin 
  • Signs of infusion reaction: fever or shaking chills, flushing, facial swelling, feeling dizzy, headache, trouble breathing, rash, itching, chest tightness, or chest pain. 
  • If you think you may be pregnant

Reproduction Warnings

  • Pregnancy warning: This drug may have harmful effects on the unborn baby. Women of child bearing potential should use effective methods of birth control during your cancer treatment and for at least 30 days after treatment. Let your doctor know right away if you think you may be pregnant
  • Breastfeeding warning: It is not known if this drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breastfeeding during treatment with this drug because this drug may enter the breast milk and cause harm to a breastfeeding baby.
  • Fertility warning:  Human fertility studies have not been done with this drug. Talk with your doctor or nurse if you plan to have children. Ask for information on sperm or egg banking

New August 2018

This patient information was developed by Via Oncology, LLC © 2018. This information is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have.

CLIENT acknowledges that the Via Pathways and Via Portal are information management tools only, and that Via Oncology, LLC has not represented the Via Pathways or Via Portal as having the ability to diagnose disease, prescribe treatment, or perform any other tasks that constitute the practice of medicine. The clinical information contained in the Via Pathways and Via Portal are intended as a supplement to, and not a substitute for, the knowledge, expertise, skill, and judgment of physicians, pharmacists and other healthcare professionals involved with patient care at CLIENT facilities.