Octreotide LAR Depot (Sandostatin® LAR Depot)

Printable PDF Version

About This Drug

Octreotide acetate is used to treat cancer. It can also be used to treat diarrhea. It is given as an injection in your muscle (intramuscularly) and in the vein (IV).

Possible Side Effects

  • Tiredness
  • Headache
  • Feeling dizzy
  • Nausea
  • Loose bowel movements (diarrhea)
  • Pain in your abdomen
  • Excess gas
  • Back pain
  • Decrease in heart rate or abnormal heartbeat may occur

Note: Each of the side effects above was reported in 20% or greater of patients treated with octreotide LAR Depot. Not all possible side effects are included above.

Warnings and Precautions

  • Inflammation of the gallbladder/gallstones. Possible signs are nausea/vomiting, fever, tenderness in the right side of the abdomen.
  • Blood sugar levels may change. If you have diabetes, changes may need to be made to your diabetes medication.
  • Changes in your thyroid function

Note: Some of the side effects above are very rare. If you have concerns and/or questions, please discuss them with your medical team.

How to Take Your Medication

  • Talk to your doctor, nurse and/or pharmacist for proper preparation, dosing and administration if you are self-injecting.
  • Storage: Store this medicine in the refrigerator, between 36°F to 46°F (2°C to 8°C). Do not freeze. Protect from light. Discuss with your nurse or your doctor how to dispose of unused  medicine/needles.

Treating Side Effects

  • Manage tiredness by pacing your activities for the day.
  • Be sure to include periods of rest between energy-draining activities.
  • If you are dizzy, get up slowly after sitting or lying.
  • Keeping your pain under control is important to your well-being. Please tell your doctor or nurse if you are experiencing pain.
  • Drink plenty of fluids (a minimum of eight glasses per day is recommended).
  • If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid).
  • If you get diarrhea, eat low-fiber foods that are high in protein and calories and avoid foods that can irritate your digestive tracts or lead to cramping.
  • Ask your nurse or doctor about medicine that can lessen or stop your diarrhea.
  • To help with nausea and vomiting, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help or stop lessen these symptoms.
  • To help with excess gas, avoid gas-producing foods, such as Brussels sprouts, cabbage, cauliflower, carrots, prunes and apricots.
  • If you have diabetes, keep good control of your blood sugar level. Tell your nurse or your doctor if your glucose levels are higher or lower than normal.

Food and Drug Interactions

  • There are no known interactions of octreotide acetate with food.
  • This drug may interact with other medicines. Tell your doctor and pharmacist about all the prescription and over-the-counter medicines and dietary supplements (vitamins, minerals, herbs and others) that you are taking at this time. The safety and use of dietary supplements and alternative diets are often not known. Using these might affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or alternative diets without your cancer doctor's help. 

When to Call the Doctor

Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:

  • Fever of 100.5 F (38 C) or higher
  • Headache that does not go away
  • Feeling dizzy or lightheaded
  • Fatigue that interferes with your daily activities
  • Feeling that your heart is beating in a fast or not normal way (palpitations)
  • Trouble breathing
  • Loose bowel movements (diarrhea) 4 times or loose bowel movements with lack of strength or a feeling of being dizzy
  • Nausea that stops you from eating or drinking and/or is not relieved by prescribed medicines
  • Throwing up more than 3 times a day
  • Pain in the right side of your abdomen
  • Abnormal blood sugar
  • Unusual thirst, passing urine often, headache, sweating, shakiness, irritability
  • If you think you may be pregnant

Reproduction Concerns

  • Pregnancy warning: It is not known if this drug may harm an unborn child. For this reason, be sure to talk with your doctor if you are pregnant or planning to become pregnant while receiving this drug. Let your doctor know right away if you think you may be pregnant.
  • Breastfeeding warning: It is not known if this drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breastfeeding during treatment with this drug because this drug may enter the breast milk and cause harm to a breastfeeding baby.
  • Fertility warning: Human fertility studies have not been done with this drug. Talk with your doctor or nurse if you plan to have children. Ask for information on sperm or egg banking.

Revised June 2018

This patient information was developed by Via Oncology, LLC © 2018. This information is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have.

CLIENT acknowledges that the Via Pathways and Via Portal are information management tools only, and that Via Oncology, LLC has not represented the Via Pathways or Via Portal as having the ability to diagnose disease, prescribe treatment, or perform any other tasks that constitute the practice of medicine. The clinical information contained in the Via Pathways and Via Portal are intended as a supplement to, and not a substitute for, the knowledge, expertise, skill, and judgment of physicians, pharmacists and other healthcare professionals involved with patient care at CLIENT facilities.