Olaratumab (Lartruvo™)

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About This Drug

Olaratumab is used to treat cancer. It is given in the vein (IV).

Possible Side Effects

• A decrease in the number of white blood cells, and platelets. This may raise your risk of infection and raise your risk of bleeding.
• Pain in your abdomen
• Nausea and vomiting (throwing up)
• Soreness of the mouth and throat. You may have red areas, white patches, or sores in your mouth that hurt.
• Diarrhea (loose bowel movements)
• Tiredness
• Decreased appetite (decreased hunger)
• Blood sugar levels may change
• Elevated blood clotting function test
• Electrolyte changes
• Muscle and bone pain
• Effects on the nerves are called peripheral neuropathy. You may feel numbness, tingling, or pain in your hands and feet. It may be hard for you to button your clothes, open jars, or walk as usual. The effect on the nerves may get worse with more doses of the drug. These effects get better in some people after the drug is stopped but it does not get better in all people.
• Headache
• Hair loss. Hair loss is often temporary, although with certain medicine, hair loss can sometimes be permanent. Hair loss may happen suddenly or gradually. If you lose hair, you may lose it on your head, face, armpits, pubic area, chest, and/or legs. You may also notice your hair getting thin.

Note: Each of the side effects above was reported in 20% or greater of patients treated with olaratumab. Not all possible side effects are included above.

Warnings and Precautions

• While you are getting this drug in your vein (IV), you may have a reaction to the drug. Sometimes you may be given medication to stop or lessen these side effects. Your nurse will check you closely for these signs: fever or shaking chills, flushing, facial swelling, feeling dizzy, headache, trouble breathing, rash, itching, chest tightness, or chest pain. These reactions may happen for 24 hours after your infusion. If this happens, call 911 for emergency care.

Important Information

• This drug may be present in the saliva, tears, sweat, urine, stool, vomit, semen, and vaginal secretions. Talk to your doctor and/or your nurse about the necessary precautions to take during this time.

Treating Side Effects

• Manage tiredness by pacing your activities for the day.
• Be sure to include periods of rest between energy-draining activities.
• To decrease the risk of infection, wash your hands regularly.
• Avoid close contact with people who have a cold, the flu, or other infections.
• Take your temperature as your doctor or nurse tells you, and whenever you feel like you may have a fever.
• To help decrease bleeding, use a soft toothbrush. Check with your nurse before using dental floss.
• Be very careful when using knives or tools.
• Use an electric shaver instead of a razor.
• Drink plenty of fluids (a minimum of eight glasses per day is recommended).
• If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack of water in the body from losing too much fluid).
• To help with nausea and vomiting, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help or stop lessen these symptoms.
• To help with decreased appetite, eat small frequent meals. Consider foods high in calories and protein, such as meat, poultry, fish, dry beans, tofu, eggs, nuts, milk, yogurt, cheese, ice cream, pudding, and nutritional supplements.
• Consider using sauces and spices to increase taste. Daily exercise, with your doctor’s approval, may increase your appetite.
• Mouth care is very important. Your mouth care should consist of routine, gentle cleaning of your teeth or dentures and rinsing your mouth with a mixture of 1/2 teaspoon of salt in 8 ounces of water or 1/2 teaspoon of baking soda in 8 ounces of water. This should be done at least after each meal and at bedtime.
• If you have mouth sores, avoid mouthwash that has alcohol. Also avoid alcohol and smoking because they can bother your mouth and throat.
• If you have diabetes, keep good control of your blood sugar level. Tell your nurse or your doctor if your glucose levels are higher or lower than normal.
• Keeping your pain under control is important to your well-being. Please tell your doctor or nurse if you are experiencing pain.
• If you have numbness and tingling in your hands and feet, be careful when cooking, walking, and handling sharp objects and hot liquids.
• To help with hair loss, wash your hair with a mild shampoo and avoid washing your hair every day.
• Avoid rubbing your scalp, instead, pat your hair or scalp dry.
• Avoid coloring your hair.
• Limit your use of hair spray, electric curlers, blow dryers, and curling irons.
• If you are interested in getting a wig, talk to your nurse. You can also call the American Cancer Society at 800-ACS-2345 to find out information about the “Look Good, Feel Better” program close to where you live. It is a free program where women getting chemotherapy can learn about wigs, turbans and scarves as well as makeup techniques and skin and nail care.

Food and Drug Interactions

• There are no known interactions of olaratumab with food.
• This drug may interact with other medicines. Tell your doctor and pharmacist about all the prescription and over-the-counter medicines and dietary supplements (vitamins, minerals, herbs and others) that you are taking at this time. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplements to make sure that there are no interactions.

When to Call the Doctor

Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:

• Fever of 100.5 F (38 C) or higher
• Chills
• Fatigue that interferes with your daily activities
• Easy bleeding or bruising
• Headache that does not go away
• Wheezing or trouble breathing
• Feeling dizzy or lightheaded
• Pain in your mouth or throat that makes it hard to eat or drink
• Nausea that stops you from eating or drinking, or is not relived by prescribed medicine
• Throwing up more than 3 times a day
• Pain in your abdomen that does not go away
• Diarrhea, 4 times in one day or diarrhea with lack of strength or a feeling of being dizzy
• Lasting loss of appetite or rapid weight loss of five pounds in a week
• Numbness, tingling, decreased feeling or weakness in fingers, toes, arms, or legs
• Abnormal blood sugar
• Unusual thirst, passing urine often, headache, sweating, shakiness, irritability
• Signs of an infusion reaction such as fever or shaking chills, flushing, facial swelling, feeling dizzy, headache, trouble breathing, rash, itching, chest tightness, or chest pain
• If you think you are pregnant

Reproduction Warnings

• Pregnancy warning: This drug can have harmful effects on the unborn baby. Women of childbearing potential should use effective methods of birth control during your cancer treatment and  for at least 3 months after treatment. Let your doctor know right away if you think you may be pregnant.
• Breastfeeding warning: Women should not breastfeed during treatment and for at least 3 months after treatment because this drug could enter the breast milk and cause harm to a breastfeeding baby.
• Fertility warning: Human fertility studies have not been done with this drug. Talk with your doctor or nurse if you plan to have children. Ask for information on sperm or egg banking.

Revised October 2018

This patient information was developed by Via Oncology, LLC © 2018. This information is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have.

CLIENT acknowledges that the Via Pathways and Via Portal are information management tools only, and that Via Oncology, LLC has not represented the Via Pathways or Via Portal as having the ability to diagnose disease, prescribe treatment, or perform any other tasks that constitute the practice of medicine. The clinical information contained in the Via Pathways and Via Portal are intended as a supplement to, and not a substitute for, the knowledge, expertise, skill, and judgment of physicians, pharmacists and other healthcare professionals involved with patient care at CLIENT facilities.