Rucaparib

Other Names: Rubraca®

About This Drug

Rucaparib is used to treat cancer. It is given orally (by mouth).

Possible Side Effects

  • Decrease in the number red blood cells, and platelets. This may make you tired and weak(fatigue), and raise your risk of bleeding.
  • Nausea and throwing up (vomiting)
  • Decreased appetite (decreased hunger)
  • Changes in the way food and drinks taste
  • Trouble breathing
  • Pain in your abdomen area
  • Constipation (not able to move bowels)
  • Loose bowel movements (diarrhea)
  • Changes in how your kidneys work. Your doctor will check your kidney function as needed.
  • Changes in your liver function. Your doctor will check your liver function as needed.
  • Increase cholesterol levels. Your doctor will check your cholesterol levels as needed.
  • Tiredness, weakness

Note: Each of the side effects above was reported in 20% or greater of patients treated with rucaparib. Not all possible side effects are included above.

Warnings and Precautions

  • This drug may raise your risk of getting a second cancer.

How to Take Your Medication

  • Swallow the medicine whole with or without food. Take this medicine twice a day, approximately 12 hours apart.
  • Missed dose: If you vomit or miss a dose, take your next dose at the regular time. Do not take 2 doses at the same time.
  • Handling: Wash your hands after handling your medicine, your caretakers should not handle your medicine with bare hands and should wear latex gloves.
  • Storage: Store this medicine in the original container at room temperature.

Treating Side Effects

  • Drink plenty of fluids (a minimum of eight glasses per day is recommended).
  • Ask your doctor or nurse about medicines that are available to help stop or lessen constipation, diarrhea and/or nausea.
  • If you are not able to move your bowels, check with your doctor or nurse before you use enemas, laxatives, or suppositories.
  • To help with nausea and vomiting, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help or stop lessen these symptoms.
  • If you get diarrhea, eat low-fiber foods that are high in protein and calories and avoid foods that can irritate your digestive tracts or lead to cramping. Ask your nurse or doctor about medicine that can lessen or stop your diarrhea.
  • Manage tiredness by pacing your activities for the day. Be sure to include periods of rest between energy-draining activities.
  • Keeping your pain under control is important to your wellbeing. Please tell your doctor or nurse if you are experiencing pain.
  • Take your temperature as your doctor or nurse tells you, and whenever you feel like you may have a fever.
  • Talk to your doctor or nurse about precautions you can take to avoid bleeding.

Food and Drug Interactions

  • There are no known interactions of rucaparib with food.
  • This drug may interact with other medicines. Tell your doctor and pharmacist about all the medicines and dietary supplements (vitamins, minerals, herbs and others) that you are taking at this time. The safety and use of dietary supplements and alternative diets are often not known. Using these might affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or alternative diets without your cancer doctor's help.

When to Call the Doctor

Call your doctor or nurse if you have any of the following symptoms and/or any new or unusual symptoms:

  • Fever of 100.5 F (38 C) or higher
  • Chills
  • Easy bleeding or bruising
  • Wheezing or trouble breathing
  • Feeling dizzy or lightheaded
  • Loose bowel movements (diarrhea) more than 4 times a day or diarrhea with weakness or lightheadedness
  • No bowel movement in 3 days or when you feel uncomfortable.
  • Lasting loss of appetite or rapid weight loss of five pounds in a week
  • Pain when passing urine; blood in urine
  • Decreased urine
  • Pain in your lower back or side
  • Nausea that stops you from eating or drinking, and/or not relieved by prescribed medicines
  • Throwing up more than 3 times a day
  • Signs of liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin
  • Heavy menstrual period that lasts longer than normal
  • Fatigue that interferes with your daily activities
  • Extreme weakness that interferes with normal activities
  • Bad abdominal pain, especially in upper right area
  • If you think you are pregnant

Reproduction Warnings

  • Pregnancy warning: This drug can have harmful effects on the unborn baby. Women of child bearing potential should use effective methods of birth control during your cancer treatment and for at least 6 months after treatment. Let your doctor know right away if you think you may be pregnant.
  • Breast feeding warning: It is not known if this drug passes into breast milk. It is recommended that women should not breastfeed during treatment and for at least 2 weeks after treatment.

New: May 2017