Sonidegib

Other Names: Odomzo®

About This Drug

Sonidegib is used to treat cancer. It is given orally (by mouth).

Possible Side Effects

  • Tiredness
  • Headache
  • Hair loss. Hair loss is often temporary, although with certain medicine, hair loss can sometimes be permanent. Hair loss may happen suddenly or gradually. If you lose hair, you may lose it from your head, face, armpits, pubic area, chest, and/or legs. You may also notice your hair getting thin.
  • Decreased appetite (decreased hunger)
  • Changes in the way food and drinks taste
  • Nausea and throwing up (vomiting).
  • Loose bowel movements (diarrhea)
  • Weight loss
  • Pain in the abdomen>
  • Muscle, bone or joint pain
  • Muscle spasm
  • Pain
  • Itching
  • Decrease in your red and white blood cells, this may make you tired and weak, and may raise your risk of infection.
  • Changes in your liver function. Your doctor will check your liver function as needed.
  • Blood sugar levels may changes. If you have diabetes, changes may need to be made to your diabetes medication.
  • This drug may affect how your kidneys work. Your kidney function will be checked as needed.

Note: Each of the side effects above was reported in 10% or greater of patients treated with sonidegib. Not all possible side effects are included above.

Warnings and Precautions

  • Rhabdomyolysis- damage to your muscles which may release proteins in your blood and affect how your kidneys work.

Important Information

  • Do not donate blood during treatment and for 20 months after treatment.

How to Take Your Medication

  • Swallow the medicine whole. Do not open the capsules. 
  • Take this drug by mouth without food, at least 1 hour before you eat or 2 hour after you eat.
  • Missed dose: If you vomit or miss a dose, take your next dose at the regular time.  
  • Handling: Wash your hands after handling your medicine, your caretakers should not handle your medicine with bare hands and should wear latex gloves.
  • This drug may be present in the saliva, tears, sweat, urine, stool, vomit, semen, and vaginal secretions. Talk to your doctor and/or your nurse about the necessary precautions to take during this time.
  • Storage: Store this medicine in the original container at room temperature. Discuss with your nurse or your doctor how to dispose of unused medicine.

Treating Side Effects

  • Manage tiredness by pacing your activities for the day. Be sure to include periods of rest between energy-draining activities.
  • To decrease your risk of infection, wash your hands regularly.
  • Avoid close contact with people who have a cold, the flu, or other infections. 
  • Take your temperature as your doctor or nurse tells you, and whenever you feel like you may have a fever.
  • Keeping your pain under control is important to your well-being. Please tell your doctor or nurse if you are experiencing pain. 
  • To help with hair loss, wash with a mild shampoo and avoid washing your hair every day.
  • Avoid rubbing your scalp, pat your hair or scalp dry.
  • Avoid coloring your hair.
  • Limit your use of hair spray, electric curlers, blow dryers, and curling irons.
  • If you are interested in getting a wig, talk to your nurse. You can also call the American Cancer Society at 800-ACS-2345 to find out information about the “Look Good, Feel Better” program close to where you live. It is a free program where women getting chemotherapy can learn about wigs, turbans and scarves as well as makeup techniques and skin and nail care.
  • Taking good care of your mouth may help food taste better and improve your appetite.
  • Drink plenty of fluids (a minimum of eight glasses per day is recommended).
  • If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid). 
  • To help with nausea and vomiting, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help or stop lessen these symptoms
  • If you get diarrhea, eat low-fiber foods that are high in protein and calories and avoid foods that can irritate your digestive tracts or lead to cramping. 
  • Ask your nurse or doctor about medicine that can lessen or stop your diarrhea.
  • To help with decreased appetite, eat small, frequent meals.
  • Eat high caloric food such as pudding, ice cream, yogurt and milkshakes.
  • If you’re diabetic, keep good control of your blood sugar level. Tell your nurse or your doctor if your glucose levels are higher or lower than normal.
  • To help with itching, moisturize your skin several times day.
  • Avoid sun exposure and apply sunscreen routinely when outdoors.

Food and Drug Interactions

  • There are no known interactions of sonidegib with food. 
  • Check with your doctor or pharmacist about all other prescription medicines and dietary supplements you are taking before starting this medicine as there are known drug interactions with sonidegib. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplement to make sure that there are no interactions.

When to Call the Doctor

Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:

  • Fever of 100.5 F (38 C) or higher 
  • Chills
  • Fatigue that interferes with your daily activities
  • Pain that does not go away or is not relieved by prescribed medicine
  • Nausea that stops you from eating or drinking  and/or is not relieved by prescribed medicines
  • Throwing up more than 3 times a day 
  • Loose bowel movements (diarrhea) 4 times a day or loose bowel movements with lack of strength or a feeling of being dizzy
  • Lasting loss of appetite or rapid weight loss of five pounds in a week 
  • Fatigue that interferes with your daily activities.
  • Feeling dizzy or lightheaded
  • Signs of possible liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin
  • Abnormal blood sugar
  • Unusual thirst, passing urine often, headache, sweating, shakiness, irritability
  • Decreased urine
  • If you think you are pregnant or if you have impregnated your partner

Reproduction Warnings

  • Pregnancy warning: This drug can have harmful effects on the unborn baby. Women of child bearing potential should use effective methods of birth control during your cancer treatment and for at least 20 months after treatment. Men with female partners of child bearing potential should use effective methods of birth control during your cancer treatment and for at least 8 months after your cancer treatment. Let your doctor know right away if you think you may be pregnant (or may have impregnated your partner).
  • Breastfeeding warning: Women should not breast feed during treatment and for 20 months after treatment because this drug could enter the breast milk and cause harm to a breast feeding baby.
  • Fertility warning: In women, this drug may affect your ability to have children in the future. Talk with your doctor or nurse if you plan to have children.  Ask for information on egg banking.

Revised July 2017