Trametinib (Mekinist®)

About This Drug

Trametinib is used to treat cancer. It is given orally (by mouth).

Possible Side Effects

  • Loose bowel movements (diarrhea)
  • Rash
  • Swelling of your legs, arms and/or face

Note: Each of the side effects above was reported in 20% or greater of patients treated with trametinib. Not all possible side effects are included above. You may experience different side effects if you take trametinib in combination with dabrafenib.

Warnings and Precautions

  • Blurred vision or other changes in eyesight, which can rarely cause blindness.
  • Changes in the tissue of the heart. Some changes may happen that can cause your heart to have less ability to pump blood.
  • Colitis, which is swelling (inflammation) in the colon - symptoms are loose bowel movements (diarrhea) stomach cramping, and sometimes blood in the bowel movements.Perforation of stomach, intestine, esophagus can rarely occur.
  • Inflammation (swelling) of the lungs. You may have a dry cough or trouble breathing.
  • Severe allergic skin reaction. You may develop blisters on your skin that are filled with fluid or a severe red rash all over your body that may be painful.
  • High blood pressure

Note: Some of the side effects above are very rare. If you have concerns and/or questions, please discuss them with your medical team. Your side effects may be different if you are taking trametinib with dabrafenib.

How to Take Your Medication

  • Take this drug by mouth without food, at least 1 hour before you eat or 2 hours after you eat.
  • Missed dose: If you miss a dose, take it as soon as you think about it, if your next dose is due in less than 12 hours, then skip the missed dose. Do not take 2 doses at the same time, instead, continue with your regular dosing schedule and contact your physician.
  • Handling: Wash your hands after handling your medicine, your caretakers should not handle your medicine with bare hands and should wear latex gloves.
  • This drug may be present in the saliva, tears, sweat, urine, stool, vomit, semen, and vaginal secretions. Talk to your doctor and/or your nurse about the necessary precautions to take during this time.
  • Storage: Store this medicine in the original container at room temperature. Discuss with your nurse or your doctor how to dispose of unused medicine

Treating Side Effects

  • Drink plenty of fluids (a minimum of eight glasses per day is recommended).
  • If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid).
  • If you get diarrhea, eat low-fiber foods that are high in protein and calories and avoid foods that can irritate your digestive tracts or lead to cramping.
  • Ask your nurse or doctor about medicine that can lessen or stop your diarrhea.
  • If you get a rash do not put anything on it unless your doctor or nurse says you may. Keep the area around the rash clean and dry. Ask your doctor for medicine if your rash bothers you.

Food and Drug Interactions

  • There are no known interactions of trametinib with food, however this medication should be taken on an empty stomach.
  • There are no known interactions of trametinib with other medications. Tell your doctor and pharmacist about all the medicines and dietary supplements (vitamins, minerals, herbs and others) that you are taking at this time. The safety and use of dietary supplements and alternative diets are often not known. Using these might affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or alternative diets without your cancer doctor's help.

When to Call the Doctor

Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:

  • Fever of 100.5 F (38 C) or higher
  • Chills
  • Blurred vision or other changes in eyesight
  • Trouble breathing
  • Dry cough
  • Feeling that your heart is beating in a fast or not normal way (palpitations)
  • Pain in your chest
  • Loose bowel movements (diarrhea) 4 times a day or loose bowel movements with lack of strength or a feeling of being dizzy
  • Severe Abdominal pain that does not go away
  • Nausea that stops you from eating or drinking or relieved by prescribed medicine
  • Throwing up more than 3 times a day
  • Pain in your abdomen that does not go away
  • Difficulty swallowing
  • Blood in your stool
  • Swelling of legs, arms, and/or face
  • Flu-like symptoms: fever, headache, muscle and joint aches, and fatigue (low energy, feeling weak)
  • A new rash or a rash that is not relieved by prescribed medicines
  • New skin lesions
  • If you think you may be pregnant

Reproduction Warnings

  • Pregnancy warning: This drug can have harmful effects on the unborn baby. Women of child bearing potential should use effective methods of birth control during your cancer treatment and for at least 4 months after treatment. Effective non-hormonal methods of birth control should be used if taking trametinib in combination with dabrafenib. Birth control pills (oral contraceptives) may not be effective with dabrafenib. Let your doctor know right away if you think you may be pregnant.
  • Breastfeeding warning: It is not known if this drug passes into breast milk. For this reason, women should not breast feed during treatment or for 4 months after treatment because this drug may enter the breast milk and cause harm to a breast feeding baby.
  • Fertility warning: In men and women both, this drug may affect your ability to have children in the future. Talk with your doctor or nurse if you plan to have children.Ask for information on sperm or egg banking.

Revised January 2018

This information is intended to provide helpful health information to the general public and is not to be used in place of any medical, health, psychological, or any other kind of personal professional services. The information herein does not cover all possible uses, actions, precautions, side effects, or interactions of the medicines mentioned, nor is the information intended as medical advice for individual problems or for making an evaluation as to the risks and benefits of taking a particular medication. The dose, method of administration and contraindications for any administered medication should be confirmed before use. UPMC specifically disclaims all responsibility for any liability, loss or risk, personal or otherwise, which is incurred as a consequence, directly or indirectly, of the use and application of any medication mentioned herein.