Encorafenib (Braftovi™)

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About This Drug

Encorafenib is used to treat cancer. It is given orally (by mouth).

Possible Side Effects

  • Tiredness
  • Nausea and vomiting (throwing up)
  • Pain in your abdomen
  • Pain in your joints
  • Decrease in the number of red blood cells. This may make you tired and weak (fatigue).
  • Changes in kidney function
  • Changes in your liver function
  • Blood sugar levels may change. If you have diabetes, changes may need to be made to your diabetes medication.

Note: Each of the side effects above was reported in 25% or greater of patients treated with encorafenib in combination with binimetinib. Not all possible side effects are included above.

Warnings and Precautions

  • This drug may raise your risk of getting a second cancer and the development of skin lesions that may or may not be cancer
  • Abnormal bleeding, which may be life-threatening – symptoms may be coughing up blood, throwing up blood (may look like coffee grounds), red or black tarry bowel movements, abnormally heavy menstrual flow, nosebleeds or any other unusual bleeding.
  • Rare, but serious reaction causing swelling in the eye
  • Abnormal heart beat/EKG
  • You may experience more severe side effects if you take encorafenib alone versus in combination with binimetinib

Note: Some of the side effects above are very rare. If you have concerns and/or questions, please discuss them with your medical team.

How to Take Your Medication

  • Swallow the medicine whole with or without food.
  • Missed dose: If you miss a dose, take it as soon as you think about it ONLY if your next dose is due in more than 12 hours. If your next dose is due in LESS than 12 hours, then skip the missed dose and take your next dose at the regular time and contact your physician. Do not take 2 doses at the same time and do not double up on the next dose.
  • If you vomit a dose, take your next dose at the regular time, and contact your physician. Do not take 2 doses at the same time and do not double up on the next dose.
  • Handling: Wash your hands after handling your medicine, your caretakers should not handle your medicine with bare hands and should wear latex gloves.
  • Storage: Store this medicine in the original container at room temperature. Protect from moistureand do not remove desiccant. Keep container tightly closed. Discuss with your nurse or your doctor how to dispose of unused medicine.

Treating Side Effects

  • Manage tiredness by pacing your activities for the day.
  • Be sure to include periods of rest between energy-draining activities.
  • Drink plenty of fluids (a minimum of eight glasses per day is recommended).
  • If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack water in the body from losing too much fluid).
  • To help with nausea and vomiting, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help or stop lessen these symptoms.
  • Keeping your pain under control is important to your well-being. Please tell your doctor or nurse if you are experiencing pain.
  • If you have diabetes, keep good control of your blood sugar level. Tell your nurse or your doctor if your glucose levels are higher or lower than normal.

Food and Drug Interactions

  • Do not eat grapefruit or drink grapefruit juice while taking this medicine. Grapefruit and grapefruit juice may raise the levels of encorafenib in your body. This could make side effects worse.
  • Check with your doctor or pharmacist about all other prescription medicines and over-the-counter medicines and dietary supplements (vitamins, minerals, herbs and others) you are taking before starting this medicine as there are known drug interactions with encorafenib. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplements to make sure that there are no interactions.
  • Avoid the use of St. John’s Wort while taking encorafenib as this may lower the levels of the drug in your body, which can make it less effective.
  • Birth control pills (oral contraceptives) may not be effective with this medication.

When to Call the Doctor

Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:

  • Blurred vision or other changes in eyesight, or to your eyes
  • Fatigue that interferes with your daily activities
  • Feeling that your heart is beating in a fast or not normal way (palpitations)
  • Nausea that stops you from eating or drinking and/or is not relieved by prescribed medicines
  • Pain in your abdomen that does not go away, or is not relieve by prescribed medicines
  • Throwing up more than 3 times a day
  • Decreased urine, or very dark urine
  • Signs of possible liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin
  • Abnormal blood sugar
  • Unusual thirst, passing urine often, headache, sweating, shakiness, irritability
  • Blood in your urine, vomit (bright red or coffee-ground) and/or stools (bright red, or black/tarry)
  • Coughing up blood
  • New skin lesions
  • Pain that does not go away, or is not relieved by prescribed medicines
  • If you think you may be pregnant

Reproduction Warnings

  • Pregnancy warning: This drug can have harmful effects on the unborn baby. Women of child bearing potential should use effective non-hormonal methods of birth control during your cancer treatment and for 2 weeks after treatment. Let your doctor know right away if you think you may be pregnant. Birth control pills (oral contraceptives) may not be effective with this medication.
  • Breastfeeding warning: Women should not breastfeed during treatment and for 2 weeks after treatment because this drug could enter the breast milk and cause harm to a breastfeeding baby.
  • Fertility warning: In men, this drug may affect your ability to have children in the future. Talk with your doctor or nurse if you plan to have children. Ask for information on sperm banking.

New July 2018

This patient information was developed by Via Oncology, LLC © 2018. This information is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have.

CLIENT acknowledges that the Via Pathways and Via Portal are information management tools only, and that Via Oncology, LLC has not represented the Via Pathways or Via Portal as having the ability to diagnose disease, prescribe treatment, or perform any other tasks that constitute the practice of medicine. The clinical information contained in the Via Pathways and Via Portal are intended as a supplement to, and not a substitute for, the knowledge, expertise, skill, and judgment of physicians, pharmacists and other healthcare professionals involved with patient care at CLIENT facilities.