Leptomeningeal Disease

What Is Leptomeningeal Disease (LMD)?

Cancer cells can travel from one part of the body to another.

LMD happens when cancer cells invade the fluid and protective membranes (called meninges) that surround the brain and spinal cord.

Contact the Neuro-Oncology Program to Make an Appointment

To learn more about brain and nervous system cancer or to make an appointment, you can:

Fill out our online contact form.


Leptomeningeal Disease (LMD) Overview


Leptomeningeal Disease (LMD) Symptoms and Diagnosis


Leptomeningeal Disease (LMD) Treatment

Doctors treat LMD with a mix of chemotherapy, surgery, and radiation.

Pain medicine and other palliative care treatments can increase your comfort.

Why Choose UPMC Hillman Cancer Center for Leptomeningeal Disease Care?

At UPMC Hillman:

  • We offer complete cancer care and state-of-the-art testing to diagnose and treat cancers — including metastatic cancers — early. This gives you the best chance at a longer and better quality life.
  • Our hub-and-spoke care model means you can stay close to home for much of your LMD treatment. We provide seamless care between our flagship in Pittsburgh and our 70+ sites across Pennsylvania, Maryland, New York, and Ohio.
  • You have access to experts from our nationally acclaimed cancer programs, including radiation, neurosurgery, and chemotherapy.
  • We work with research partners across the country. This means we can offer newer, more promising treatment options as soon as they come to market.