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Avatrombopag (Doptelet®)

About This Drug

Avatrombopag is used to increase platelets. It is given orally (by mouth).

Possible Side Effects

  • Headache
  • Tiredness
  • Pain in your joints
  • Nosebleed
  • Bleeding in the gums
  • Upper respiratory infection
  • Tiny red spots on the skin, often from low platelets
  • Inflammation of the nasal passages and throat

Note: Each of the side effects above was reported in 10% or greater of patients treated with avatrombopag. Not all possible side effects are included above.

Warnings and Precautions

  • Blood clots and events such as stroke and heart attack. A blood clot in your leg may cause your leg to swell, appear red and warm, and/or cause pain. A blood clot in your lungs may cause trouble breathing, pain when breathing, and/or chest pain.

Note: Some of the side effects above are very rare. If you have concerns and/or questions, please discuss them with your medical team. 

How to Take Your Medication

  • Swallow the medicine whole with food.
  • Missed dose: If you miss a dose, take it as soon as you think about it. Do not take 2 doses at the same time and do not double up on the next dose. If you miss a dose, contact your doctor. If you are taking this medicine to treat low platelets due to chronic liver disease, make sure you complete all 5 days of dosing.
  • Handling: Wash your hands after handling your medicine, your caretakers should not handle your medicine with bare hands and should wear latex gloves.
  • Storage: Store this medicine in the original container at room temperature.
  • Disposal of unused medicine: Do not flush any expired and/or unused medicine down the toilet or drain unless you are specifically instructed to do so on the medication label. Some facilities have take-back programs and/or other options. If you do not have a take-back program in your area, then please discuss with your nurse or your doctor how to dispose of unused medicine.

Treating Side Effects

  • Keeping your pain under control is important to your well-being. Please tell your doctor or nurse if you are experiencing pain.
  • Manage tiredness by pacing your activities for the day.
  • Be sure to include periods of rest between energy-draining activities.
  • Drink plenty of fluids (a minimum of eight glasses per day is recommended).
  • If you have a nose bleed, sit with your head tipped slightly forward. Apply pressure by lightly pinching the bridge of your nose between your thumb and forefinger. Call your doctor if you feel dizzy or faint or if the bleeding doesn’t stop after 10 to 15 minutes.

Food and Drug Interactions

  • This drug may interact with grapefruit and grapefruit juice. Talk to your doctor as this could make side effects worse.
  • Check with your doctor or pharmacist about all other prescription medicines and over-the-counter medicines and dietary supplements (vitamins, minerals, herbs and others) you are taking before starting this medicine as there are known drug interactions with avatrombopag. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplements to make sure that there are no interactions.
  • This drug may interact with St. John’s Wort and may lower the levels of avatrombopag in your body. Talk to your doctor as this could make avatrombopag less effective.

When to Call the Doctor

Call your doctor or nurse if you have and of these symptoms and/or any new or unusual symptoms:

  • Fever of 100.4° F (38° C) or higher
  • Headache that does not go away
  • Tiredness that interferes with your daily activities
  • Pain that does not go away, or is not relieved by prescribed medicines
  • Wheezing and/or trouble breathing
  • Coughing up yellow, green, or bloody mucus
  • Nose bleed that doesn’t stop bleeding after 10 -15 minutes
  • Feeling dizzy or lightheaded
  • Coughing up yellow, green, or bloody mucus
  • Chest pain or symptoms of a heart attack. Most heart attacks involve pain in the center of the chest that lasts more than a few minutes. The pain may go away and come back. It can feel like pressure, squeezing, fullness, or pain. Sometimes pain is felt in one or both arms, the back, neck, jaw, or stomach. If any of these symptoms last 2 minutes, call 911.
  • Symptoms of a stroke such as sudden numbness or weakness of your face, arm, or leg, mostly on one side of your body; sudden confusion, trouble speaking or understanding; sudden trouble seeing in one or both eyes; sudden trouble walking, feeling dizzy, loss of balance or coordination; or sudden, bad headache with no known cause. If you have any of these symptoms for 2 minutes, call 911.
  • Your leg or arm is swollen, red, warm and/or painful
  • Any new tiny red spots on the skin
  • If you think you may be pregnant

Reproduction Warnings

  • Pregnancy warning: This drug may have harmful effects on the unborn baby. Women of childbearing potential should use effective methods of birth control during your treatment. Let your doctor know right away if you think you may be pregnant.
  • Breastfeeding warning: Women should not breastfeed during treatment and for 2 weeks after treatment because this drug could enter the breast milk and cause harm to a breastfeeding baby.
  • Fertility warning: Human fertility studies have not been done with this drug. Talk with your doctor or nurse if you plan to have children. Ask for information on sperm or egg banking. 

Revised August 2019

This patient information was developed by Via Oncology, LLC © 2019. This information is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have.

CLIENT acknowledges that the Via Pathways and Via Portal are information management tools only, and that Via Oncology, LLC has not represented the Via Pathways or Via Portal as having the ability to diagnose disease, prescribe treatment, or perform any other tasks that constitute the practice of medicine. The clinical information contained in the Via Pathways and Via Portal are intended as a supplement to, and not a substitute for, the knowledge, expertise, skill, and judgment of physicians, pharmacists and other healthcare professionals involved with patient care at CLIENT facilities.