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Belantamab mafodotin-blmf (Blenrep)

About This Drug

Belantamab mafodotin-blmf is used to treat cancer. It is given in the vein (IV).

Possible Side Effects

  • Bone marrow suppression. This is a decrease in the number of white blood cells, red blood cells, and platelets. This may raise your risk of infection, make you tired and weak (fatigue), and raise your risk of bleeding.
  • Changes to the cornea leading to vision changes
  • Blurred or decreased vision
  • Nausea
  • Tiredness
  • Fever
  • While you are getting this drug in your vein (IV), you may have a reaction to the drug. Sometimes you may be given medication to stop or lessen these side effects. Your nurse will check you closely for these signs: fever or shaking chills, flushing, facial swelling, feeling dizzy, headache, trouble breathing, rash, itching, chest tightness, or chest pain. These reactions may happen after your infusion. If this happens, call 911 for emergency care.
  • Changes in your liver and/or kidney function

Note: Each of the side effects above was reported in 20% or greater of patients treated with belantamab mafodotin-blmf. Not all possible side effects are included above.

Warnings and Precautions

  • Severe vision problems such as dry eyes, blurred vision, worsening vision and/or vision loss, and ulcers on your cornea.
  • Decrease in the number of platelets. This may raise your risk of bleeding and can be life-threatening.
  • Severe infusion-related reactions

Note: Some of the side effects above are very rare. If you have concerns and/or questions, please discuss them with your medical team.

Important Information

  • You will need to sign up for a special program called Blenrep REMS when you start taking this drug. Your nurse will help you get started.
  • This drug may impair your ability to drive or use machinery. Use caution and tell your nurse or doctor if you have any changes in your eyesight.
  • You should use preservative-free lubricant eye drops at least 4 times a day during your treatment. It is important that you see an eye specialist before and during your treatment. Discuss with your doctor and/or nurse for more information.
  • It is recommended to avoid wearing contact lenses during treatment unless told otherwise by your eye specialist.
  • This drug may be present in the saliva, tears, sweat, urine, stool, vomit, semen, and vaginal secretions. Talk to your doctor and/or your nurse about the necessary precautions to take during this time. 

Treating Side Effects

  • Manage tiredness by pacing your activities for the day.
  • Be sure to include periods of rest between energy-draining activities.
  • To decrease the risk of infection, wash your hands regularly.
  • Avoid close contact with people who have a cold, the flu, or other infections.
  • Take your temperature as your doctor or nurse tells you, and whenever you feel like you may have a fever.
  • To help decrease the risk of bleeding, use a soft toothbrush. Check with your nurse before using dental floss.
  • Be very careful when using knives or tools.
  • Use an electric shaver instead of a razor.
  • Drink plenty of fluids (a minimum of eight glasses per day is recommended).
  • To help with nausea, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help stop or lessen these symptoms.
  • Infusion reactions may happen after your infusion. If this happens, call 911 for emergency care.

Food and Drug Interactions

  • There are no known interactions of belantamab mafodotin-blmf with food.
  • This drug may interact with other medicines. Tell your doctor and pharmacist about all the prescription and over-the-counter medicines and dietary supplements (vitamins, minerals, herbs and others) that you are taking at this time. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplements to make sure that there are no interactions.

When to Call the Doctor

Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:

  • Fever of 100.4° F (38° C) or higher
  • Chills
  • Tiredness that interferes with your daily activities
  • Feeling dizzy or lightheaded
  • Easy bleeding or bruising
  • Dry eyes
  • Blurred vision or any other changes in eyesight
  • Nausea that stops you from eating or drinking and/or is not relieved by prescribed medicines
  • Signs of infusion reaction: fever or shaking chills, flushing, facial swelling, feeling dizzy, headache, trouble breathing, rash, itching, chest tightness, or chest pain. These reactions may happen after your infusion. If this happens, call 911 for emergency care.
  • Signs of possible liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin
  • Decreased or very dark urine
  • If you think you may be pregnant or may have impregnated your partner

Reproduction Warnings

  • Pregnancy warning: This drug may have harmful effects on the unborn baby. Women of childbearing potential should use effective methods of birth control during your cancer treatment and for 4 months after treatment. Men with female partners of childbearing potential should use effective methods of birth control during your cancer treatment and for 6 months after your cancer treatment. Let your doctor know right away if you think you may be pregnant or may have impregnated your partner.
  • Breastfeeding warning: It is not known if this drug passes into breast milk. For this reason, women should not breastfeed during treatment and for 3 months after treatment because this drug could enter the breast milk and cause harm to a breastfeeding baby. 
  • Fertility warning: In men and women both, this drug may affect your ability to have children in the future. Talk with your doctor or nurse if you plan to have children. Ask for information on sperm or egg banking.

New August 2020

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