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Lanreotide (Somatuline® Depot)

About This Drug

Lanreotide is used to treat cancer and acromegaly. It is given an injection under the skin (subcutaneously), usually in the buttock area.

Possible Side Effects

  • Nausea and vomiting (throwing up)
  • Diarrhea (loose bowel movements)
  • Pain in your abdomen
  • Muscle spasm
  • Injection site reaction - you may get a rash, swelling or bruising or your skin may get red, warm, itchy or painful at the site of your infusion or injection
  • Inflammation of the gallbladder/gallstones. Possible signs are nausea/vomiting, fever, tenderness in the right side of the abdomen.
  • Blood sugar levels may change
  • Joint, bone and muscle pain
  • Headache
  • Feeling dizzy
  • High blood pressure

Note: Each of the side effects above was reported in 5% or greater of patients treated with lanreotide. Not all possible side effects are included above.

Warnings and Precautions

  • Inflammation of the gallbladder and complications from gallstones such as infection and inflammation of your pancreas
  • Blood sugar levels may change
  • Decrease in heart rate may occur
  • Changes in your thyroid function

Treating Side Effects

  • Keeping your pain under control is important to your well-being. Please tell your doctor or nurse if you are experiencing pain.
  • Drink plenty of fluids (a minimum of eight glasses per day is recommended).
  • If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack of water in the body from losing too much fluid).
  • If you have diarrhea, eat low-fiber foods that are high in protein and calories and avoid foods that can irritate your digestive tracts or lead to cramping.
  • Ask your nurse or doctor about medicine that can lessen or stop your diarrhea.
  • To help with nausea and vomiting, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help stop or lessen these symptoms.
  • If you have diabetes, keep good control of your blood sugar level. Tell your nurse or your doctor if your glucose levels are higher or lower than normal.
  • If you are dizzy, get up slowly after sitting or lying.

Food and Drug Interactions

  • There are no known interactions of lanreotide with food.
  • This drug may interact with other medicines. Tell your doctor and pharmacist about all the prescription and over-the-counter medicines and dietary supplements (vitamins, minerals, herbs and others) that you are taking at this time. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplements to make sure that there are no interactions.

When to Call the Doctor

Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:

  • Fever of 100.4° F (38° C) or higher
  • Feeling dizzy or lightheaded
  • Headache that does not go away
  • Blurry vision or other changes in eyesight
  • Tiredness that interferes with your daily activities
  • Diarrhea, 4 times a day or diarrhea with lack of strength or a feeling of being dizzy
  • Nausea that stops you from eating or drinking and/or is not relieved by prescribed medicines
  • Throwing up more than 3 times a day
  • Pain in the right side of your abdomen
  • Pain that does not go away or is not relieved by prescribed medicine
  • Unexplained weight gain
  • Abnormal blood sugar
  • Unusual thirst, passing urine often, headache, sweating, shakiness, irritability
  • While you are getting this drug, please tell your nurse right away if you get a rash, swelling or bruising or your skin gets red, warm, itchy or painful at the site of your infusion or injection
  • If you think you may be pregnant

Reproduction Concerns

  • Pregnancy warning: It is not known if this drug may harm an unborn child. For this reason, be sure to talk with your doctor if you are pregnant or planning to become pregnant while receiving this drug.
  • Breastfeeding warning: Women should not breastfeed during treatment and for 6 months after treatment because this drug could enter the breast milk and cause harm to a breastfeeding baby.
  • Fertility warning: In women, this drug may affect your ability to have children in the future. Talk with your doctor or nurse if you plan to have children. Ask for information on egg banking.

Revised July 2019

This patient information was developed by Via Oncology, LLC © 2019. This information is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have.

CLIENT acknowledges that the Via Pathways and Via Portal are information management tools only, and that Via Oncology, LLC has not represented the Via Pathways or Via Portal as having the ability to diagnose disease, prescribe treatment, or perform any other tasks that constitute the practice of medicine. The clinical information contained in the Via Pathways and Via Portal are intended as a supplement to, and not a substitute for, the knowledge, expertise, skill, and judgment of physicians, pharmacists and other healthcare professionals involved with patient care at CLIENT facilities.