Other Names: (Poteligeo®)
About This Drug
Mogamulizumab-kpkc is used to treat cancer. It is given in the vein (IV).
Possible Side Effects
- Bone marrow suppression. This is a decrease in the number of white blood cells, red blood cells, and platelets. This may raise your risk of infection, make you feel more tired, and may raise your risk of bleeding.
- Diarrhea (loose bowel movements)
- While you are getting this drug in your vein (IV), you may have a reaction to the drug. Sometimes you may be given medication to stop or lessen these side effects. Your nurse will check you closely for these signs: fever or shaking chills, flushing, facial swelling, feeling dizzy, headache, trouble breathing, rash, itching, chest tightness, or chest pain. These reactions may happen after your infusion. If this happens, call 911 for emergency care.
- Changes in your liver function
- Blood sugar levels may change. If you have diabetes, changes may need to be made to your diabetes medication.
- Electrolyte changes
- Bone, joint and muscle pain
- Upper respiratory tract infection
Note: Each of the side effects above was reported in 20% or greater of patients treated with mogamulizumab-kpkc. Not all possible side effects are included above.
Warnings and Precautions
- Severe allergic skin reaction, which can be life-threatening. You may develop blisters on your skin that are filled with fluid or a severe red rash all over your body that may be painful.
- Severe infusion reactions which can be life-threatening
- Severe infections which can be life-threatening
- This drug increases your risk of developing a new autoimmune disorder or can worsen an existing autoimmune disorder. This may put you at risk for developing serious medical problems, which can be life-threatening.
- Increased risk of life-threatening complications in patients who will undergo a stem cell transplant after receiving mogamulizumab-kpkc.
Note: Some of the side effects above are very rare. If you have concerns and/or questions, please discuss them with your medical team.
Treating Side Effects
- To decrease the risk of infection, wash your hands regularly.
- Avoid close contact with people who have a cold, the flu, or other infections.
- Take your temperature as your doctor or nurse tells you, and whenever you feel like you may have a fever
- Manage tiredness by pacing your activities for the day.
- Be sure to include periods of rest between energy-draining activities.
- To decrease the risk of bleeding, use a soft toothbrush. Check with your nurse before using dental floss.
- Be very careful when using knives or tools.
- Use an electric shaver instead of a razor.
- Drink plenty of fluids (a minimum of eight glasses per day is recommended).
- If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack of water in the body from losing too much fluid).
- If you have diarrhea, eat low-fiber foods that are high in protein and calories and avoid foods that can irritate your digestive tracts or lead to cramping.
- Ask your nurse or doctor about medicine that can lessen or stop your diarrhea.
- Infusion reactions may occur after your infusion. If this happens, call 911 for emergency care.
- If you get a rash do not put anything on it unless your doctor or nurse says you may. Keep the area around the rash clean and dry. Ask your doctor for medicine if your rash bothers you.
- Keeping your pain under control is important to your well-being. Please tell your doctor or nurse if you are experiencing pain.
- Keep good control of your blood sugar level. Tell your nurse or your doctor if your glucose levels are higher or lower than normal.
Food and Drug Interactions
- There are no known interactions of mogamulizumab-kpkc with food.
- This drug may interact with other medicines. Tell your doctor and pharmacist about all the prescription and over-the-counter medicines and dietary supplements (vitamins, minerals, herbs and others) that you are taking at this time. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplements to make sure that there are no interactions.
- The safety and use of dietary supplements and alternative diets are often not known. Using these might affect your cancer or interfere with your treatment. Do not use dietary supplements or alternative diets without your cancer doctor's help.
When to Call the Doctor
Call your doctor or nurse if you have any of the following symptoms and/or any new or unusual symptoms:
- Fever of 100.5 F (38 C) or above
- Signs of a local infection such as pain, redness, tenderness, warmth and/or swelling
- Flu-like symptoms: fever, headache, muscle and joint aches, and fatigue (low energy, feeling weak)
- Wheezing or trouble breathing
- Coughing up yellow, green, or bloody mucus
- Fatigue that interferes with your daily activities
- Feeling dizzy or lightheaded
- Easy bleeding or bruising
- Abnormal blood sugar
- Unusual thirst, passing urine often, headache, sweating, shakiness, irritability
- Diarrhea 4 times in a day or loose bowel movements with lack of strength or a feeling of being dizzy
- Signs of infusion reaction: fever or shaking chills, flushing, facial swelling, feeling dizzy, headache, trouble breathing, rash, itching, chest tightness, or chest pain.
- New rash and/or itching
- Rash that is not relieved by prescribed medicines
- Pain that does not go away, or is not relieved by prescribed medicines
- Signs of possible liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin
- If you think you may be pregnant
- Pregnancy warning: This drug may have harmful effects on the unborn baby. Women of child bearing potential should use effective methods of birth control during your cancer treatment and for at least 3 months after treatment. Let your doctor know right away if you think you may be pregnant.
- Breastfeeding warning: It is not known if this drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breastfeeding during treatment with this drug because this drug may enter the breast milk and cause harm to a breastfeeding baby.
- Fertility warning: Human fertility studies have not been done with this drug. Talk with your doctor or nurse if you plan to have children. Ask for information on sperm or egg banking.
New August 2018
This patient information was developed by Via Oncology, LLC © 2018. This information is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have.
CLIENT acknowledges that the Via Pathways and Via Portal are information management tools only, and that Via Oncology, LLC has not represented the Via Pathways or Via Portal as having the ability to diagnose disease, prescribe treatment, or perform any other tasks that constitute the practice of medicine. The clinical information contained in the Via Pathways and Via Portal are intended as a supplement to, and not a substitute for, the knowledge, expertise, skill, and judgment of physicians, pharmacists and other healthcare professionals involved with patient care at CLIENT facilities.