Nilutamide (Nilandron®)

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About This Drug

Nilutamide is used to treat cancer. It is given orally (by mouth).

Possible Side Effects

  • Hot flashes or sudden skin flushing may happen. You may also feel warm or red.
  • You may have difficulty seeing when going from a lighted area to a dark area.

Note: Each of the side effects above was reported in 10% or greater of patients treated with nilutamide and surgical castration. Not all possible side effects are included above..

Warnings and Precautions

  • Inflammation (swelling) of the lungs. You may have a dry cough or trouble breathing.
  • Changes in your liver function, which can be life-threatening.

Important Information

  • Do not stop taking nilutamide without first talking with your doctor.
  • This drug may impair your ability to drive, especially at night or through tunnels. Use caution and tell your nurse or doctor if you experience this effect.
  • Nilutamide may cause intolerance to alcohol. Alcohol should be avoided if you experience hot flashes, skin flushing, general discomfort or have a feeling of being unwell after drinking alcohol.

How to Take Your Medication

  • Swallow the medicine whole with or without food.
  • Missed dose: If you vomit or miss a dose, contact your physician. Do not take 2 doses at the same time and do not double up on the next dose.
  • Handling: Wash your hands after handling your medicine, your caretakers should not handle your medicine with bare hands and should wear latex gloves.
  • Storage: Store this medicine in the original container at room temperature. Protect from light.
  • Disposal of unused medicine: Do not flush any expired and/or unused medicine down the toilet or drain unless you are specifically instructed to do so on the medication label. Some facilities have take-back programs and/or other options. If you do not have a take-back program in your area, then please discuss with your nurse or your doctor how to dispose of unused medicine.

Food and Drug Interactions

  • There are no known interactions of nilutamide with food.
  • Check with your doctor or pharmacist about all other prescription medicines and over-the-counter medicines and dietary supplements (vitamins, minerals, herbs and others) you are taking  before starting this medicine as there are known drug interactions with nilutamide. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplements to make sure that there are no interactions.
  • There are known interactions of nilutamide with blood thinning medicine such as warfarin. Ask your doctor what precautions you should take.

When to Call the Doctor

Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:

  • Fever of 100.4 F (38 C) or higher
  • Chills
  • Pain in your chest
  • Dry cough
  • Trouble breathing
  • Signs of possible liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin
  • If you think you may have impregnated your partner

Reproduction Warnings

  • Pregnancy warning: IIt is not known if this drug may harm an unborn child. Nilutamide should not be used by women. Men with female partners of childbearing potential should talk to their doctor about effective methods of birth control. Let your doctor know right away if you think you have impregnated your partner.
  • Breastfeeding warning: It is not known if this drug passes into breast milk. Nilutamide should not be used by women and should not be used during breastfeeding.
  • Fertility warning: Human fertility studies have not been done with this drug. Talk with your doctor or nurse if you plan to have children. Ask for information on sperm or egg banking.

Revised June 2019

This patient information was developed by Via Oncology, LLC © 2019. This information is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have.

CLIENT acknowledges that the Via Pathways and Via Portal are information management tools only, and that Via Oncology, LLC has not represented the Via Pathways or Via Portal as having the ability to diagnose disease, prescribe treatment, or perform any other tasks that constitute the practice of medicine. The clinical information contained in the Via Pathways and Via Portal are intended as a supplement to, and not a substitute for, the knowledge, expertise, skill, and judgment of physicians, pharmacists and other healthcare professionals involved with patient care at CLIENT facilities.