Pegfilgrastim-xxxx (Neulasta®, Neulasta® Onpro®, Fulphila™, Udenyca™)

Printable PDF Version

About This Drug

Pegfilgrastim-xxxx belongs to a class of medicines called granulocyte colony-stimulating factor (G-CSF). G-CSF helps the body make more white blood cells. White blood cells help fight infection in your body. This drug is given as an injection under the skin (subcutaneously).

Possible Side Effects

  • Bone pain
  • Pain in your arms and/or legs

Note: Each of the side effects above was reported in 5% or greater of patients treated with pegfilgrastim-xxxx. Not all possible side effects are included above.

Warnings and Precautions

  • Enlargement and inflammation (swelling) of your spleen, which can very rarely rupture and be life-threatening. Signs of enlargement may be left-sided pain in your abdomen and/or shoulder.
  • Trouble breathing because of fluid build-up around your lungs and/or inflammation (swelling) of the lungs.
  • Allergic reactions, including anaphylaxis are rare but may happen in some patients. Signs of allergic reaction to this drug may be swelling of the face, feeling like your tongue or throat are swelling, trouble breathing, rash, itching, fever, chills, feeling dizzy, and/or feeling that your heart is beating in a fast or not normal way. If this happens, do not take another dose of this drug. You should get urgent medical treatment.
  • Sickle cell crisis in sickle cell patients treated with pegfilgrastim-xxxx
  • Changes in your kidney function
  • A rapid increase in your white blood cells may happen
  • A syndrome where fluid and protein can leak from your blood vessels into your tissues. This can cause a decrease in your blood protein level and blood pressure and fluid can accumulate in your tissues and/or lungs.
  • The on-body injector uses acrylic adhesive. Caution should be used if you have an allergy to acrylic adhesives.
  • Missed or partial doses of the medication have been reported from the on-body injector device not working properly. This could increase your risk of developing severely low white blood cells,  which puts you at a risk of severe and life-threatening infections. If you have any problems with the on body injector, contact your doctor and/or nurse right away.
  • Inflammation of the aorta- symptoms may include fever, abdominal pain, back pain and feeling tired.

Note: Some of the side effects above are very rare. If you have concerns and/or questions, please discuss them with your medical team.

How to Take Your Medication

  • Talk to your doctor, nurse and/or pharmacist for proper preparation, dosing, administration if you are using the on-body injector. It is important that you follow the instructions and precautions closely. 

Treating Side Effects

  • Keeping your pain under control is important to your well-being. Please tell your doctor or nurse if you are experiencing pain.

Food and Drug Interactions

  • There are no known interactions of pegfilgrastim-xxxx with food.
  • Tell your doctor and pharmacist about all the prescription and over-the-counter medicines and dietary supplements (vitamins, minerals, herbs and others) that you are taking at this time. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplements to make sure that there are no interactions. 
  • The safety and use of dietary supplements and alternative diets are often not known. Using these might affect your cancer or interfere with your treatment. Until more is known, you should not use dietary supplements or alternative diets without your cancer doctor's help.

When to Call the Doctor

Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:

  • Fever of 100.5 F (38 C) or higher
  • Chills
  • Cough
  • Wheezing and/or trouble breathing
  • Feeling dizzy or lightheaded
  • Fatigue that interferes with your daily activities
  • Pain in your left-sided abdomen and/or shoulder pain
  • Back pain
  • Decreased urine, or very dark urine
  • Pain that does not go away or is not relieved by prescribed medicine
  • Swelling of legs, ankles, or feet
  • Signs of allergic reaction: swelling of the face, feeling like your tongue or throat are swelling, trouble breathing, rash, itching, fever, chills, feeling dizzy, and/or feeling that your heart is beating in a fast or not normal way
  • If you think you may be pregnant

Reproduction Warnings

  • Pregnancy warning: It is not known if this drug may harm an unborn child. For this reason, be sure to talk with your doctor if you are pregnant or planning to become pregnant while receiving this drug. Let your doctor know right away if you think you may be pregnant.
  • Breastfeeding warning: It is not known if this drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breastfeeding during treatment with this drug because this drug may enter the breast milk and cause harm to a breastfeeding baby.
  • Fertility warning: Human fertility studies have not been done with this drug. Talk with your doctor or nurse if you plan to have children. Ask for information on sperm or egg banking.

Revised November 2018