Other Names: Xermelo®
About This Drug
Telotristat ethyl is used to treat diarrhea in patients with carcinoid syndrome. It is given orally (by mouth).
Possible Side Effects
- Decreased appetite (decreased hunger)
- Excess gas
- Swelling of your legs, ankles and/or feet
- Changes in your liver function
Note: Each of the side effects above was reported in 5% or greater of patients treated with telotristat ethyl. Not all possible side effects are included above.
Warnings and Precautions
- Constipation (not able to move bowels)
How to Take Your Medication
- Take your medicine with food.
- If you are taking this medicine with short-acting octreotide, take the short-acting octreotide at least 30 minutes after telotristat ethyl.
- Missed doses: If you vomit or miss a dose, take your next dose at the regular time, and contact your physician. Do not take 2 doses at the same time and do not double up on the next dose.
- Handling: Wash your hands after handling your medicine. Caretakers should not handle your medicine with bare hands and should wear latex gloves.
- Storing: Store this medicine in the original container at room temperature.
- Disposal of unused medicine: Do not flush any expired and/or unused medicine down the toilet or drain unless you are specifically instructed to do so on the medication label. Some facilities have take-back programs and/or other options. If you do not have a take-back program in your area, then please discuss with your nurse or your doctor how to dispose of unused medicine.
Treating Side Effects
- Drink plenty of fluids (a minimum of eight glasses per day is recommended).
- If you throw up or have loose bowel movements, you should drink more fluids so that you do not become dehydrated (lack of water in the body from losing too much fluid).
- To help with nausea, eat small, frequent meals instead of three large meals a day. Choose foods and drinks that are at room temperature. Ask your nurse or doctor about other helpful tips and medicine that is available to help stop or lessen these symptoms.
- To help with decreased appetite, eat small, frequent meals. Eat foods high in calories and protein, such as meat, poultry, fish, dry beans, tofu, eggs, nuts, milk, yogurt, cheese, ice cream, pudding, and nutritional supplements.
- Consider using sauces and spices to increase taste. Daily exercise, with your doctor’s approval, may increase your appetite.
- To help with excess gas, avoid gas-producing foods such as brussels sprouts, cabbage, cauliflower, carrots, prunes, and apricots.
- If you are not able to move your bowels, check with your doctor or nurse before you use enemas, laxatives, or suppositories.
- Ask your doctor or nurse about medicines that are available to help stop or lessen constipation.
- Keeping your pain under control is important to your well-being. Please tell your doctor or nurse if you are experiencing pain.
- If you are feeling depressed, talk to your nurse or doctor about it.
Food and Drug Interactions
- There are no known interactions of telotristat ethyl with food, however, this medication should be taken with food.
- Check with your doctor or pharmacist about all other prescription medicines and over-the-counter medicines and dietary supplements (vitamins, minerals, herbs, and others) you are taking before starting this medicine as there are known drug interactions with telotristat ethyl. Also, check with your doctor or pharmacist before starting any new prescription or over-the-counter medicines, or dietary supplements to make sure that there are no interactions.
When to Call the Doctor
Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms:
- Fever of 100.4° F (38° C) or higher
- Headache that does not go away
- Tiredness that interferes with your daily activities
- Lose interest in your daily activities that you used to enjoy and feeling this way every day, and/or you feel hopelessness.
- Nausea that stops you from eating and drinking and/or that is not relieved by prescribed medicine
- Severe abdominal pain/cramping
- Excess gas or pain in your abdomen that does not go away
- No bowel movement in 3 days or when you feel uncomfortable
- Lasting loss of appetite or rapid weight loss of five pounds in a week
- Weight gain of 5 pounds in one week (fluid retention)
- Swelling of your legs, ankles and/or feet
- Signs of possible liver problems: dark urine, pale bowel movements, bad stomach pain, feeling very tired and weak, unusual itching, or yellowing of the eyes or skin
- If you think you are pregnant
- Pregnancy warning: It is not known if this drug may harm an unborn child. For this reason, be sure to talk with your doctor if you are pregnant or planning to become pregnant while getting this drug. Let your doctor know right away if you think you may be pregnant.
- Breastfeeding warning: It is not known if this drug passes into breast milk. For this reason, women should talk to their doctor about the risks and benefits of breastfeeding during treatment with this drug because this drug may enter the breast milk and cause harm to a breastfeeding baby. If you are breastfeeding, monitor your baby for signs of constipation.
- Fertility warning: Human fertility studies have not been done with this drug. Talk with your doctor or nurse if you plan to have children.
Revised August 2019
This patient information was developed by Via Oncology, LLC © 2019. This information is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have.
CLIENT acknowledges that the Via Pathways and Via Portal are information management tools only, and that Via Oncology, LLC has not represented the Via Pathways or Via Portal as having the ability to diagnose disease, prescribe treatment, or perform any other tasks that constitute the practice of medicine. The clinical information contained in the Via Pathways and Via Portal are intended as a supplement to, and not a substitute for, the knowledge, expertise, skill, and judgment of physicians, pharmacists and other healthcare professionals involved with patient care at CLIENT facilities.